Dr. Johannes ZUBER Research Group Leader, IMP - Research Institute of Molecular Pathology, Vienna
CV
| 2001-2005 | Clinical Internship & Residency (Arzt im Praktikum & Assistenzarzt) in Hematology and Oncology, Charité University Hospital, Berlin |
| Clinical training in general oncology, hematology and hemostaseology, high-dose chemotherapy, stem-cell transplantation and intensive care medicine | |
| 2005-2008 | Postdoctoral Research Fellow, Laboratory of Scott W. Lowe, PhD Cold Spring Harbor Laboratory, Cold Spring Harbor, New York |
| Development of genetically engineered leukemia mouse models; studies on mechanisms in leukemogenesis and drug resistance; RNAi technology (new vector systems, RNAi Sensor assay, in-vivo RNAi screening, custom shRNA libraries) | |
| 2009-2010 | Clinical Research Fellow, Cold Spring Harbor Laboratory, New York |
| In-vivo RNAi studies in leukemia mouse models and transgenic RNAi models. Multiplexed negative-selection RNAi screening, RNAi-based in-vivo validation of candidate therapeutic targets. Chromatin regulators in leukemia maintenance | |
| since 2011 | Research Group Leader, IMP - Research Institute of Molecular Pathology, Vienna |
Publikationen
| Zuber J*, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, Magoon D, Qi J, Blatt K, Wunderlich M, Taylor MJ, Johns C, Chicas A, Mulloy JC, Kogan SC, Brown P, Valent P, Bradner JE, Lowe SW, Vakoc CR: RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia, Nature. 2011;478(7370):524-528. doi: 10.1038/nature10334 | |
| Zuber J*, McJunkin K*, Fellmann C, Dow LE, Taylor MJ, Hannon GJ, Lowe SW: Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi, Nature Biotechnology. 2011;29(1):79-83. doi: 10.1038/nbt.1720 | |
| Zuber J*, Rappaport AR*, Luo W, Wang E, Chen C, Vaseva AV, Shi J, Weissmueller S, Fellmann C, Taylor MJ, Weissenboeck M, Graeber TG, Kogan SC, Vakoc CR, Lowe SW: An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance, Genes & Development. 2011;25(15):1628-1640. doi: 10.1101/gad.17269211 | |
| Zuber J, Radtke I, Pardee TS, Zhao Z, Rappaport AR, Luo W, McCurrach ME, Yang MM, Dolan ME, Kogan SC, Downing JR, Lowe SW: Mouse models of human AML accurately predict chemotherapy response, Genes & Development |
Auszeichnungen
| Dr. med. degree awarded with summa cum laude, 2003 | |
| Research Fellowship of the DFG (Deutsche Forschungsgemeindschaft), 2006-2008 | |
| Ambassador Felix Schnyder Grant (Lauri Strauss Leukemia Foundation), 2006-2007 | |
| CSHL Andrew Seligson Memorial Clinical Research Fellowship, 2009-2010 |
